PDBe 3mo8

X-ray diffraction
1.69Å resolution

PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55201 (Residues: 1079-1207; Coverage: 11%)
Gene names: BR140, BRPF1
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.
Histone H3.2 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q71DI3 (Residues: 31-42; Coverage: 9%)
Gene names: H3F2, H3FM, HIST2H3A, HIST2H3C, HIST2H3D

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I222
Unit cell:
a: 43.086Å b: 70.605Å c: 113.539Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.207
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided