PDBe 3lww

X-ray diffraction
3.15Å resolution

Structure of an open and closed conformation of Human Importin Beta bound to the Snurportin1 IBB-domain trapped in the same crystallographic asymmetric unit

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit beta-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 876 amino acids
Theoretical weight: 97.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14974 (Residues: 1-876; Coverage: 100%)
Gene names: KPNB1, NTF97
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Snurportin-1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 40 amino acids
Theoretical weight: 5.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O95149 (Residues: 25-64; Coverage: 11%)
Gene names: RNUT1, SNUPN, SPN1
Sequence domains: Snurportin1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1, NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 101.65Å b: 101.735Å c: 101.963Å
α: 90° β: 110.88° γ: 90°
R-values:
R R work R free
0.266 0.264 0.313
Expression systems:
  • Escherichia coli
  • Not provided