PDBe 3lw1

X-ray diffraction
1.28Å resolution

Binary complex of 14-3-3 sigma and p53 pT387-peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein sigma Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-248; Coverage: 100%)
Gene names: HME1, SFN
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain
Cellular tumor antigen p53 Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 385-393; Coverage: 2%)
Gene names: P53, TP53

Ligands and Environments

3 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 82.32Å b: 112.32Å c: 62.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.128 0.126 0.151
Expression systems:
  • Escherichia coli
  • Not provided