› 3lpw

X-ray diffraction
1.65Å resolution

Crystal structure of the FnIII-tandem A77-A78 from the A-band of titin

Released:
DOI: 10.2210/pdb3lpw/pdb
PDB entry 3lpw coloured by chain, front view.
PDB entry 3lpw coloured by chain, side view.
PDB entry 3lpw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin.
Bucher RM, Svergun DI, Muhle-Goll C, Mayans O
J Mol Biol 401 843-53 (2010)
PMID: 20542041

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 21.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZ42 (Residues: 22877-23070; Coverage: 1%)
Gene name: TTN
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand MPD 2 x MPD
Ligand MRD 1 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-20
Spacegroup: C2221
Unit cell:
a: 115.9Å b: 163.2Å c: 65.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.179 0.208
Expression system: Escherichia coli

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Citations

2 review citations

The giant protein titin: a regulatory node that integrates myocyte signaling pathways.
Krüger et al. (2011)
1 more

5 mentions without citation

Structure of giant muscle proteins.
Meyer et al. (2013)
4 more