PDBe 3l5x

X-ray diffraction
1.9Å resolution

Crystal structure of the complex between IL-13 and H2L6 FAB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35225 (Residues: 35-146; Coverage: 100%)
Gene names: IL13, NC30
Structure domains: Growth Hormone; Chain: A;
H2L6 HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 24.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
H2L6 LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 63.78Å b: 73.02Å c: 114.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.197 0.247
Expression systems:
  • Escherichia coli
  • Homo sapiens