PDBe 3l3x

X-ray diffraction
1.55Å resolution

Crystal structure of DHT-bound androgen receptor in complex with the first motif of steroid receptor coactivator 3

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 250 amino acids
Theoretical weight: 29.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 671-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 3 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.37 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y6Q9 (Residues: 618-629; Coverage: 1%)
Gene names: AIB1, BHLHE42, NCOA3, RAC3, TRAM1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 57.314Å b: 66.704Å c: 73.137Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.206
Expression systems:
  • Escherichia coli
  • Not provided