PDBe 3kxz

X-ray diffraction
2.37Å resolution

The complex crystal structure of LCK with a probe molecule w259

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 33.21 KDa
Source organism: Homo sapiens
Expression system: Baculoviridae
UniProt:
  • Canonical: P06239 (Residues: 225-509; Coverage: 56%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 42.012Å b: 73.784Å c: 84.717Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.261
Expression system: Baculoviridae