PDBe 3kwy

X-ray diffraction
2.3Å resolution

Crystal structure of RXRalpha ligand binding domain in complex with triphenyltin and a coactivator fragment

Released:
Source organism: Homo sapiens
Primary publication:
A structural view of nuclear hormone receptor: endocrine disruptor interactions.
Cell. Mol. Life Sci. 67 1219-37 (2010)
PMID: 20063036

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 27.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P43212
Unit cell:
a: 64.635Å b: 64.635Å c: 113.589Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.244
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided