PDBe 3kvq

X-ray diffraction
2.7Å resolution

Crystal structure of VEGFR2 extracellular domain D7

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35968 (Residues: 657-764; Coverage: 8%)
Gene names: FLK1, KDR, VEGFR2
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I212121
Unit cell:
a: 39.476Å b: 76.989Å c: 102.035Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.23 0.296
Expression system: Escherichia coli