PDBe 3ktm

X-ray diffraction
2.7Å resolution

Structure of the Heparin-induced E1-Dimer of the Amyloid Precursor Protein (APP)

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 191 amino acids
Theoretical weight: 21.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 18-190; Coverage: 23%)
Gene names: A4, AD1, APP
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: R3
Unit cell:
a: 143.99Å b: 143.99Å c: 351.19Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.215 0.25
Expression system: Escherichia coli