PDBe 3koh

X-ray diffraction
2.9Å resolution

Cytochrome P450 2E1 with omega-imidazolyl octanoic acid

Released:

Function and Biology Details

Reaction catalysed:
4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2E1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 476 amino acids
Theoretical weight: 55.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05181 (Residues: 32-493; Coverage: 94%)
Gene names: CYP2E, CYP2E1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P43
Unit cell:
a: 71.185Å b: 71.185Å c: 224.862Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.206 0.292
Expression system: Escherichia coli