PDBe 3kmz

X-ray diffraction
2.1Å resolution

Crystal structure of RARalpha ligand binding domain in complex with the inverse agonist BMS493 and a corepressor fragment

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 29.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10276 (Residues: 176-421; Coverage: 53%)
Gene names: NR1B1, RARA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor corepressor 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 19 amino acids
Theoretical weight: 2.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75376 (Residues: 2047-2065; Coverage: 1%)
Gene names: KIAA1047, NCOR1

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 104.831Å b: 105.625Å c: 53.382Å
α: 90° β: 89.92° γ: 90°
R-values:
R R work R free
0.175 0.172 0.23
Expression systems:
  • Escherichia coli
  • Not provided