PDBe 3kgt

X-ray diffraction
1.95Å resolution

V30M mutant human transthyretin (TTR) complexed with genistein (V30M:GEN) pH 7.5

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: P21212
Unit cell:
a: 43.27Å b: 85.07Å c: 64.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.241
Expression system: Escherichia coli