PDBe 3kfv

X-ray diffraction
2.8Å resolution

Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form

Source organism: Homo sapiens
Entry authors: Tong Y, Nedyalkova L, Tempel W, Zhong N, Guan X, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tight junction protein ZO-3 Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 35.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: O95049 (Residues: 474-775; Coverage: 33%)
Gene names: TJP3, ZO3
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P422
Unit cell:
a: 88.654Å b: 88.654Å c: 92.311Å
α: 90° β: 90° γ: 90°
R R work R free
0.225 0.222 0.29
Expression system: Escherichia coli BL21