PDBe 3k9x

X-ray diffraction
1.9Å resolution

X-ray crystal structure of human fxa in complex with (S)-N-((2-METHYLBENZOFURAN-5-YLAMINO)(2-OXO-1-(2-OXO-2- (PYRROLIDIN-1-YL)ETHYL)AZEPAN-3- YLAMINO)METHYLENE)NICOTINAMIDE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Factor X light chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 94 amino acids
Theoretical weight: 10.21 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 85-178; Coverage: 21%)
Gene name: F10
Sequence domains:
Structure domains: Laminin
Activated factor Xa heavy chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 238 amino acids
Theoretical weight: 26.87 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-472; Coverage: 52%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P21
Unit cell:
a: 62.263Å b: 77.63Å c: 73.732Å
α: 90° β: 102.63° γ: 90°
R-values:
R R work R free
0.177 0.176 0.24