PDBe 3k35

X-ray diffraction
2Å resolution

Crystal Structure of Human SIRT6

Released:
Source organism: Homo sapiens
Primary publication:
Structure and biochemical functions of SIRT6.
J. Biol. Chem. 286 14575-87 (2011)
PMID: 21362626

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacetylase sirtuin-6 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 318 amino acids
Theoretical weight: 35.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N6T7 (Residues: 3-318; Coverage: 89%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 89.388Å b: 136.266Å c: 89.26Å
α: 90° β: 119.87° γ: 90°
R-values:
R R work R free
0.202 0.202 0.267
Expression system: Escherichia coli BL21(DE3)