PDBe 3jti

X-ray diffraction
1.8Å resolution

Crystal structure of the complex formed between Phospholipase A2 with beta-amyloid fragment, Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met at 1.8 A resolution

Source organisms:
Entry authors: Pandey N, Mirza Z, Vikram G, Singh N, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP

Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acidic phospholipase A2 3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.13 KDa
Source organism: Naja sagittifera
  • Canonical: P60045 (Residues: 8-126; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2
P3(40) Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 803 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P05067 (Residues: 699-706; Coverage: 1%)
Gene names: A4, AD1, APP

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.762Å b: 42.762Å c: 65.765Å
α: 90° β: 90° γ: 90°
R R work R free
0.173 0.171 0.21
Expression system: Not provided