PDBe 3jql

X-ray diffraction
1.2Å resolution

Crystal Structure of the Complex Formed Between Phospholipase A2 and a Hexapeptide Fragment of Amyloid Beta Peptide, Lys-Leu-Val-Phe-Phe-Ala at 1.2 A Resolution

Released:
Source organisms:
Entry authors: Mirza Z, Vikram G, Singh N, Sinha M, Sharma S, Srinivasan A, Kaur P, Singh TP

Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
P3(40) Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 725 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 687-692; Coverage: 1%)
Gene names: A4, AD1, APP
Acidic phospholipase A2 3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.13 KDa
Source organism: Naja sagittifera
UniProt:
  • Canonical: P60045 (Residues: 8-126; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.023Å b: 42.023Å c: 64.146Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.181 0.193
Expression system: Not provided