PDBe 3jq5

X-ray diffraction
2.03Å resolution

Phospholipase A2 Prevents the Aggregation of Amyloid Beta Peptides: Crystal Structure of the Complex of Phospholipase A2 with Octapeptide Fragment of Amyloid Beta Peptide, Asp-Ala-Glu-Phe-Arg-His-Asp-Ser at 2 A Resolution

Source organisms:
Entry authors: Mirza Z, Vikram G, Singh N, Sinha M, Bhushan A, Sharma S, Srinivasan A, Kaur P, Singh TP

Function and Biology Details

Reaction catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amyloid-beta protein 40 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 978 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P05067 (Residues: 672-679; Coverage: 1%)
Gene names: A4, AD1, APP
Acidic phospholipase A2 3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.13 KDa
Source organism: Naja sagittifera
  • Canonical: P60045 (Residues: 8-126; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 42.795Å b: 42.795Å c: 65.832Å
α: 90° β: 90° γ: 90°
R R work R free
0.185 0.182 0.221
Expression system: Not provided