PDBe 3j70

Electron Microscopy
20Å resolution

Model of gp120, including variable regions, in complex with CD4 and 17b

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 15-mer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
monoclonal antibody 17b light chain Chains: A, M, R
Molecule details ›
Chains: A, M, R
Length: 212 amino acids
Theoretical weight: 22.64 KDa
Source organism: Homo sapiens
monoclonal antibody 17b heavy chain Chains: B, N, S
Molecule details ›
Chains: B, N, S
Length: 210 amino acids
Theoretical weight: 22.82 KDa
Source organism: Homo sapiens
T-cell surface glycoprotein CD4 Chains: C, O, T
Molecule details ›
Chains: C, O, T
Length: 185 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-208; Coverage: 42%)
Gene name: CD4
Sequence domains: Immunoglobulin C2-set domain
Surface protein gp120 Chains: D, P, U
Molecule details ›
Chains: D, P, U
Length: 470 amino acids
Theoretical weight: 52.57 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: P04578 (Residues: 31-500; Coverage: 57%)
Gene name: env
envelope glycoprotein gp41 Chains: E, Q, V
Molecule details ›
Chains: E, Q, V
Length: 140 amino acids
Theoretical weight: 11.93 KDa
Source organism: Human immunodeficiency virus 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20Å
Relevant EMDB volumes: EMD-5020