PDBe 3j63

Electron Microscopy
3.8Å resolution

Unified assembly mechanism of ASC-dependent inflammasomes


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 15-mer (preferred)
Entry contents:
1 distinct polypeptide molecule
Apoptosis-associated speck-like protein containing a CARD Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
Length: 91 amino acids
Theoretical weight: 10.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9ULZ3 (Residues: 1-91; Coverage: 47%)
Gene names: ASC, CARD5, PYCARD, TMS1
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-5830
Expression system: Escherichia coli