› 3ipx

X-ray diffraction
2Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
ATP + deoxyadenosine = ADP + dAMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-151057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidine kinase Chain: A
Molecule details ›
Chain: A
Length: 241 amino acids
Theoretical weight: 28.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P27707 (Residues: 20-260; Coverage: 93%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand B86 1 x B86
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P43212
Unit cell:
a: 80.238Å b: 80.238Å c: 93.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.278

Quick links

Citations

1 review citation

Urgency and austerity as drivers of success.
Stouch TR. (2017)
2 other articles

1 mention without citation

Computational simulation and target prediction studies of solubility optimization of decitabine through supercritical solvent.
Alshahrani et al. (2022)