PDBe 3io6

X-ray diffraction
3.7Å resolution

Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Maltose-binding periplasmic protein; Huntingtin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 449 amino acids
Theoretical weight: 49.32 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P42858 (Residues: 1-13, 14-64; Coverage: 2%)
  • Canonical: P0AEX9 (Residues: 27-384; Coverage: 97%)
  • nullnull
Gene names: HD, HTT, IT15, JW3994, b4034, malE
Sequence domains: Bacterial extracellular solute-binding protein
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 163.401Å b: 101.242Å c: 138.19Å
α: 90° β: 92° γ: 90°
R-values:
R R work R free
0.248 0.245 0.293
Expression system: Escherichia coli