PDBe 3ifq

X-ray diffraction
2.8Å resolution

Interction of plakoglobin and beta-catenin with desmosomal cadherins

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Junction plakoglobin Chains: A, B
Molecule details ›
Chains: A, B
Length: 553 amino acids
Theoretical weight: 60.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14923 (Residues: 124-676; Coverage: 74%)
Gene names: CTNNG, DP3, JUP
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
E-Cad/CTF3 Chains: C, D
Molecule details ›
Chains: C, D
Length: 107 amino acids
Theoretical weight: 12.06 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P09803 (Residues: 778-884; Coverage: 12%)
Gene name: Cdh1

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 76.043Å b: 76.15Å c: 122.94Å
α: 90° β: 97.15° γ: 90°
R-values:
R R work R free
0.2 0.194 0.261
Expression system: Escherichia coli