› 3hyd

X-ray diffraction
1Å resolution

LVEALYL peptide derived from human insulin chain B, residues 11-17

Released:
DOI: 10.2210/pdb3hyd/pdb
PDB entry 3hyd coloured by chain, front view.
PDB entry 3hyd coloured by chain, side view.
PDB entry 3hyd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for insulin fibril assembly.
Ivanova MI, Sievers SA, Sawaya MR, Wall JS, Eisenberg D
Proc Natl Acad Sci U S A 106 18990-5 (2009)
PMID: 19864624

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin B chain Chain: A
Molecule details ›
Chain: A
Length: 7 amino acids
Theoretical weight: 820 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 35-41; Coverage: 8%)
Gene name: INS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 49.478Å b: 4.838Å c: 19.442Å
α: 90° β: 96.65° γ: 90°
R-values:
R R work R free
0.149 0.146 0.18
Expression system: Not provided

Quick links

Citations

22 review citations

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade.
Chiti et al. (2017)
21 more

14 mentions without citation

Molecular basis for insulin fibril assembly.
Ivanova et al. (2009)
13 more