PDBe 3hvl

X-ray diffraction
2.1Å resolution

Tethered PXR-LBD/SRC-1p complexed with SR-12813

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor coactivator 1; Nuclear receptor subfamily 1 group I member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 344 amino acids
Theoretical weight: 39.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75469 (Residues: 130-434; Coverage: 70%)
  • Canonical: Q15788 (Residues: 678-700; Coverage: 2%)
  • nullnull
Gene names: BHLHE74, NCOA1, NR1I2, PXR, SRC1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 85.44Å b: 88.84Å c: 105.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.22 0.265
Expression system: Escherichia coli