PDBe 3hob

X-ray diffraction
2.07Å resolution

Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Factor VIIIa light chain Chains: A, M
Molecule details ›
Chains: A, M
Length: 159 amino acids
Theoretical weight: 18.03 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P00451 (Residues: 2189-2347; Coverage: 7%)
Gene names: F8, F8C
Sequence domains: F5/8 type C domain
Structure domains: Galactose-binding domain-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 43.279Å b: 58.988Å c: 60.086Å
α: 90° β: 110.65° γ: 90°
R-values:
R R work R free
0.22 0.217 0.263
Expression system: Komagataella pastoris