PDBe 3hm8

X-ray diffraction
2.8Å resolution

Crystal structure of the C-terminal Hexokinase domain of human HK3

Released:
Source organism: Homo sapiens
Entry authors: Nedyalkova L, Tong Y, Rabeh W, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 445 amino acids
Theoretical weight: 48.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52790 (Residues: 480-922; Coverage: 48%)
Gene name: HK3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P41
Unit cell:
a: 83.904Å b: 83.904Å c: 323.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.27
Expression system: Escherichia coli