PDBe 3hi7

X-ray diffraction
1.8Å resolution

Crystal structure of human diamine oxidase

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amiloride-sensitive amine oxidase [copper-containing] Chains: A, B
Molecule details ›
Chains: A, B
Length: 731 amino acids
Theoretical weight: 83.46 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P19801 (Residues: 21-751; Coverage: 100%)
Gene names: ABP1, AOC1, DAO1
Sequence domains:
Structure domains:

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 92.506Å b: 94.784Å c: 196.525Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.161 0.189
Expression system: Drosophila melanogaster