PDBe 3hhr

X-ray diffraction
2.8Å resolution

HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Somatotropin Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 22 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01241 (Residues: 27-216; Coverage: 100%)
Gene name: GH1
Structure domains: Growth Hormone; Chain: A;
Growth hormone-binding protein Chains: B, C
Molecule details ›
Chains: B, C
Length: 205 amino acids
Theoretical weight: 24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10912 (Residues: 50-254; Coverage: 33%)
Gene name: GHR
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 145.8Å b: 68.6Å c: 76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 not available
Expression system: Not provided