PDBe 3h2u

X-ray diffraction
2.75Å resolution

Human raver1 RRM1, RRM2, and RRM3 domains in complex with human vinculin tail domain Vt

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ribonucleoprotein PTB-binding 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 283 amino acids
Theoretical weight: 31.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IY67 (Residues: 39-321; Coverage: 47%)
Gene names: KIAA1978, RAVER1
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits
Vinculin Chains: A, C
Molecule details ›
Chains: A, C
Length: 188 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P18206 (Residues: 944-1134; Coverage: 17%)
  • Best match: P18206-2 (Residues: 879-1066)
Gene name: VCL
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 86.754Å b: 94.906Å c: 186.027Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.224 0.274
Expression system: Escherichia coli