PDBe 3h1v

X-ray diffraction
2.11Å resolution

Human glucokinase in complex with a synthetic activator


Function and Biology Details

Reaction catalysed:
ATP + D-glucose = ADP + D-glucose 6-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Glucokinase Chain: X
Molecule details ›
Chain: X
Length: 451 amino acids
Theoretical weight: 50.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P35557 (Residues: 16-465; Coverage: 97%)
Gene name: GCK
Sequence domains: Hexokinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P6522
Unit cell:
a: 79.793Å b: 79.793Å c: 326.124Å
α: 90° β: 90° γ: 120°
R R work R free
0.235 0.232 0.284
Expression system: Escherichia coli