PDBe 3gqy

X-ray diffraction
1.85Å resolution

Activator-Bound Structure of Human Pyruvate Kinase M2

Released:
Source organism: Homo sapiens
Entry authors: Hong B, Dimov S, Tempel W, Auld D, Thomas C, Boxer M, Jianq J-K, Skoumbourdis A, Min S, Southall N, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Inglese J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 550 amino acids
Theoretical weight: 60.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: Rigaku FR-E
Spacegroup: P21
Unit cell:
a: 81.149Å b: 152.952Å c: 93.159Å
α: 90° β: 103.28° γ: 90°
R-values:
R R work R free
0.213 0.213 0.238
Expression system: Escherichia coli