PDBe 3gic

X-ray diffraction
1.55Å resolution

Structure of thrombin mutant delta(146-149e) in the free form

Released:
Source organism: Homo sapiens
Primary publication:
Stabilization of the E* form turns thrombin into an anticoagulant.
J. Biol. Chem. 284 20034-40 (2009)
PMID: 19473969

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin heavy chain Chain: B
Molecule details ›
Chain: B
Length: 250 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 42%)
Gene name: F2
Structure domains: Trypsin-like serine proteases
Thrombin light chain Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P43
Unit cell:
a: 58.229Å b: 58.229Å c: 119.559Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.22
Expression system: Cricetulus griseus