PDBe 3g6d

X-ray diffraction
3.2Å resolution

Crystal structure of the complex between CNTO607 Fab and IL-13

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-13 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35225 (Residues: 35-146; Coverage: 100%)
Gene names: IL13, NC30
Structure domains: Growth Hormone; Chain: A;
CNTO607 Fab Heavy chain Chain: H
Molecule details ›
Chain: H
Length: 229 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
CNTO607 Fab Light chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 22.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 66.54Å b: 68.03Å c: 182.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.263
Expression systems:
  • Escherichia coli
  • Homo sapiens