PDBe 3g5y

X-ray diffraction
1.59Å resolution

Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Epidermal growth factor receptor Chain: E
Molecule details ›
Chain: E
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00533 (Residues: 311-326; Coverage: 1%)
Gene names: EGFR, ERBB, ERBB1, HER1
175 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 216 amino acids
Theoretical weight: 23.37 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
175 light chain Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.26 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21212
Unit cell:
a: 83.176Å b: 69.267Å c: 71.477Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.196 0.25
Expression systems:
  • Not provided
  • Mus musculus