PDBe 3g5v

X-ray diffraction
2Å resolution

Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
806 light chain Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
Structure domains: Immunoglobulins
808 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 213 amino acids
Theoretical weight: 22.78 KDa
Source organism: Mus musculus
Expression system: Mus musculus
UniProt:
Structure domains: Immunoglobulins
Epidermal growth factor receptor Chain: C
Molecule details ›
Chain: C
Length: 16 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00533 (Residues: 311-326; Coverage: 1%)
Gene names: EGFR, ERBB, ERBB1, HER1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 35.925Å b: 83.161Å c: 72.214Å
α: 90° β: 92.43° γ: 90°
R-values:
R R work R free
0.229 0.226 0.279
Expression systems:
  • Mus musculus
  • Not provided