PDBe 3fy2

X-ray diffraction
1.8Å resolution

Human EphA3 Kinase and Juxtamembrane Region Bound to Substrate KQWDNYEFIW

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 41.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains: Protein tyrosine kinase
Structure domains:
peptide substrate Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.43 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 53.824Å b: 38.261Å c: 76.365Å
α: 90° β: 102.05° γ: 90°
R-values:
R R work R free
0.181 0.179 0.212
Expression systems:
  • Escherichia coli
  • Not provided