PDBe 3fhr

X-ray diffraction
1.9Å resolution

High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3 (MK3)-inhibitor complex


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
MAP kinase-activated protein kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 38.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q16644 (Residues: 33-349; Coverage: 83%)
Gene name: MAPKAPK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 84.688Å b: 74.832Å c: 60.664Å
α: 90° β: 107.34° γ: 90°
R R work R free
0.228 0.226 0.267
Expression system: Escherichia coli