PDBe 3fav

X-ray diffraction
2.15Å resolution

Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ESAT-6-like protein EsxB Chains: A, C
Molecule details ›
Chains: A, C
Length: 101 amino acids
Theoretical weight: 10.87 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycobacterium smegmatis str. MC2 155
UniProt:
  • Canonical: P9WNK5 (Residues: 1-100; Coverage: 100%)
Gene names: MTV027.09, Rv3874, cfp10, esxB, lhp, mtsA10
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6 like
6 kDa early secretory antigenic target Chains: B, D
Molecule details ›
Chains: B, D
Length: 94 amino acids
Theoretical weight: 9.78 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycobacterium smegmatis str. MC2 155
UniProt:
  • Canonical: P9WNK7 (Residues: 2-95; Coverage: 99%)
Gene names: MTV027.10, Rv3875, esaT6, esxA
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6 like

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 160.34Å b: 23.93Å c: 83.86Å
α: 90° β: 94.36° γ: 90°
R-values:
R R work R free
0.199 0.199 0.233
Expression system: Mycobacterium smegmatis str. MC2 155