PDBe 3f5p

X-ray diffraction
2.9Å resolution

Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor


Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
Entry contents:
1 distinct polypeptide molecule
Insulin-like growth factor 1 receptor beta chain Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, R, S, T
Length: 308 amino acids
Theoretical weight: 35.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P08069 (Residues: 981-1286; Coverage: 23%)
Gene name: IGF1R
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 137.34Å b: 137.02Å c: 178.99Å
α: 90° β: 110.36° γ: 90°
R R work R free
0.212 0.21 0.258
Expression system: Homo sapiens