PDBe 3eto

X-ray diffraction
2Å resolution

2 Angstrom Xray structure of the NOTCH1 Negative Regulatory Region (NRR)


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Notch 1 extracellular truncation Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P46531 (Residues: 1446-1733; Coverage: 10%)
Gene names: NOTCH1, TAN1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 169.927Å b: 91.759Å c: 59.844Å
α: 90° β: 109.38° γ: 90°
R R work R free
0.213 0.211 0.252
Expression system: Escherichia coli