PDBe 3epz

X-ray diffraction
2.31Å resolution

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1


Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA (cytosine-5)-methyltransferase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 30.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P26358 (Residues: 351-600; Coverage: 16%)
Gene names: AIM, CXXC9, DNMT, DNMT1
Sequence domains: Cytosine specific DNA methyltransferase replication foci domain
Structure domains: Arc Repressor Mutant, subunit A

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 57.544Å b: 59.768Å c: 96.286Å
α: 90° β: 92.31° γ: 90°
R R work R free
0.216 0.213 0.264
Expression system: Escherichia coli