› 3eb0

X-ray diffraction
2.65Å resolution

Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804

Released:
DOI: 10.2210/pdb3eb0/pdb
PDB entry 3eb0 coloured by chain, front view.
PDB entry 3eb0 coloured by chain, side view.
PDB entry 3eb0 coloured by chain, top view.
Source organism: Cryptosporidium parvum Iowa II
Entry authors: Wernimont AK, Fedorov O, Lam A, Ali A, Zhao Y, Lew J, Wasney G, Vedadi M, Kozieradzki I, Schapira M, Bochkarev A, Wilstrom M, Bountra C, Arrowsmith CH, Edwards AM, Hui R, Lin YH, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107148 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 383 amino acids
Theoretical weight: 43.83 KDa
Source organism: Cryptosporidium parvum Iowa II
Expression system: Escherichia coli
UniProt:
  • Canonical: A3FQN0 (Residues: 52-433; Coverage: 88%)
Gene name: cgd4_240
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DRK 2 x DRK
Ligand GOL 4 x GOL
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21212
Unit cell:
a: 134.101Å b: 138.366Å c: 43.261Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.238 0.295
Expression system: Escherichia coli

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