PDBe 3e6p

X-ray diffraction
2.1Å resolution

Crystal structure of human meizothrombin desF1

Released:
Source organism: Homo sapiens
Primary publication:
Na+ binding to meizothrombin desF1.
Cell. Mol. Life Sci. 65 3688-97 (2008)
PMID: 18854941

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activation peptide fragment 2 Chain: L
Molecule details ›
Chain: L
Length: 158 amino acids
Theoretical weight: 17.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 206-363; Coverage: 26%)
Gene name: F2
Sequence domains:
Structure domains:
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P41212
Unit cell:
a: 121.336Å b: 121.336Å c: 100.204Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.211 0.249
Expression system: Cricetulus griseus