PDBe 3e63

X-ray diffraction
1.9Å resolution

Fragment based discovery of JAK-2 inhibitors

Source organism: Homo sapiens
Primary publication:
Fragment-based discovery of JAK-2 inhibitors.
Bioorg. Med. Chem. Lett. 19 279-82 (2009)
PMID: 19019674

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.68 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
  • Canonical: O60674 (Residues: 839-1131; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2221
Unit cell:
a: 93.304Å b: 102.795Å c: 67.991Å
α: 90° β: 90° γ: 90°
R R work R free
0.203 0.199 0.263
Expression system: unidentified baculovirus