PDBe 3e04

X-ray diffraction
1.95Å resolution

Crystal structure of human fumarate hydratase

Released:
Source organism: Homo sapiens
Entry authors: Kavanagh KL, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fumarate hydratase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 490 amino acids
Theoretical weight: 52.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07954 (Residues: 44-510; Coverage: 92%)
Gene name: FH
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 188.483Å b: 188.483Å c: 114.632Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.197 0.244
Expression system: Escherichia coli