PDBe 3dxd

X-ray diffraction
2.2Å resolution

Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
C31 Chains: B, D
Molecule details ›
Chains: B, D
Length: 35 amino acids
Theoretical weight: 4.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 739-770; Coverage: 4%)
Gene names: A4, AD1, APP
Amyloid-beta A4 precursor protein-binding family B member 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 140 amino acids
Theoretical weight: 15.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00213 (Residues: 534-667; Coverage: 19%)
Gene names: APBB1, FE65, RIR
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P61
Unit cell:
a: 115.115Å b: 115.115Å c: 75.254Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.247
Expression system: Escherichia coli