PDBe 3do4

X-ray diffraction
2.4Å resolution

Crystal structure of transthyretin variant T60A at acidic pH

Source organism: Homo sapiens
Entry authors: Cendron L, Zanotti G, Folli C, Berni R

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transthyretin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 127 amino acids
Theoretical weight: 13.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 60.586Å b: 75.907Å c: 107.267Å
α: 90° β: 93.1° γ: 90°
R R work R free
0.205 0.202 0.267
Expression system: Escherichia coli