PDBe 3dlx

X-ray diffraction
2.2Å resolution

Crystal structure of human 3-oxoacid CoA transferase 1

Released:
Source organism: Homo sapiens
Entry authors: Kavanagh KL, Shafqat N, Yue WW, Picaud S, Murray JW, Maclean EM, von Delft F, Roos AK, Arrowsmith CH, Wikstrom M, Edwards AM, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 489 amino acids
Theoretical weight: 53.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55809 (Residues: 40-520; Coverage: 93%)
Gene names: OXCT, OXCT1, SCOT
Sequence domains: Coenzyme A transferase
Structure domains: Glutaconate Coenzyme A-transferase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 60.956Å b: 168.492Å c: 95.322Å
α: 90° β: 105.86° γ: 90°
R-values:
R R work R free
0.179 0.178 0.225
Expression system: Escherichia coli BL21(DE3)